Safety and immunogenicity of Salmonella typhi Ty21a vaccine in young Thai children.
نویسندگان
چکیده
Salmonella typhi Ty21a vaccine in a liquid formulation was evaluated in 634 Thai children 2 to 6 years of age. The seroconversion rate was 69% for those who received vaccine versus 14% for those who received placebo (P < 0.005). The immune responses among vaccine recipients ranged from 60% in 3-year-olds to 81% for 6-year-olds.
منابع مشابه
Immunogenicity of Salmonella typhi Ty21a vaccine for young children.
An attenuated Salmonella typhi Ty21a vaccine was administered to 18 infants and toddlers (less than or equal to 24 months old) to determine its safety and immunogenicity. The vaccination (10(9) CFU per dose, three doses) was well tolerated. However, after the vaccination there was no evidence of a humoral or cellular immune response to S. typhi. The vaccine used was known to be immunogenic for ...
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عنوان ژورنال:
- Infection and immunity
دوره 61 3 شماره
صفحات -
تاریخ انتشار 1993